GASTRO-RETENTIVE FORMULATION OF METOCLOPRAMIDE: DESIGN AND OPTIMIZATION USING D-OPTIMAL DESIGN TECHNIQUE
Vinay Wamorkar, Manjunath S. Yallagatti, MohanVarma
1 Srikrupa Institute of Pharmaceutical Sciences, Vill: Velekatta, MDL: Kondapak, RD: Siddipet, Dist: Medak, AP 502277, India. 2 Vishnu College of Pharmacy, Bhimavaram, Dist: West Godavari, AP, India.
Keywords: Gastro-retentive, D-Optimal, Metoclopramide, Release Kinetics, zero order
Abstract

The purpose of this research was to fabricate and optimize Gastro-retentive drug delivery system for Metoclopramide Hydrochloride. The effect of ethyl cellulose and sodium alginate on the drug release profile and floating properties was evaluated. Sodium carbonate was incorporated as gas generating agent. The addition of ethyl cellulose reduces the drug dissolution rate due to its hydrophobic nature. A D-Optimal Technique was applied systematically to optimize the drug release profile. The amounts of ethyl cellulose (X1) and sodium alginate (X2) were selected as independent variables. The cumulative percent of drug released at 8, 12 and 16 hours were selected as dependent variables. The study shows that, tablet composition and mechanical strength have great influence on floating properties and drug release. All formulations were evaluated for dimensional analysis, duration of buoyancy, floating lag time, drug content and in-vitro drug release. Optimized formulation’s data was subjected to various release kinetic models. The drug release was sufficiently sustained for 24 hours. Model equations of zero and first order, Higuchi, Hixson-Crowell and Peppas, intended to elucidate the drug release mechanism, were fitted to the release data. The zero order release was observed with r2 values of 0.98. The difference in the release pattern and kinetics can be explained by the different swelling and erosion behaviors.

Article Information

Identifiers and Pagination:
Year:2012
Volume:4
First Page:109
Last Page:123
Publisher Id:JAppPharm (2012 ). 4. 109-123
Article History:
Received:November 7, 2011
Accepted:January 13, 2012
Collection year:2011
First Published:January 20, 2012


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

Bibliography

Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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