EFFECT OF ENHANCERS AND IONTOPHORESIS ON CAPTOPRIL PERMEABILITY THROUGH EXCISED PIG SKIN
Ashish Jain, Satish Nayak, Vandana Soni
1 Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal-462021, India. 2 Department of Pharmaceutical Sciences, Dr H.S.Gour Vishwavidyalaya, Sagar 470003, M.P. India
Keywords: Captopril, iontophoresis, transdermal, chemical enhancers.
Abstract

In vitro transdermal delivery of captopril across excised pig skin using various enhancers investigated. Permeation studies carried out at the modified franz diffusion cell. Steady state fluxes, permeability coefficients, diffusion coefficients, benefits and enhancement ratios by various enhancers were determined. Incorporation of various permeability enhancers like dimethyl sulfoxide, peppermint oil, menthol, oleic acid, sodium louryl sulphate, poly ethylene glycol with pure drug solution showed synergistic effect when combined with iontophoresis. Dimethyl sulfoxide was the most active enhancer, and when combined with iontophoresis it was possible to deliver 103.940 mmol/cm2 of drug at the end of 8 hours, it was 4.4 times enhancement as compare to delivery of drug without enhancers.

Article Information

Identifiers and Pagination:
Year:2012
Volume:4
First Page:131
Last Page:142
Publisher Id:JAppPharm (2012 ). 4. 131-142
Article History:
Received:January 7, 2012
Accepted:March 17, 2012
Collection year:2012
First Published:April 1, 2012


© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. You are free to: Share — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. No additional restrictions You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits
Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

Bibliography

Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights

Subject & Scope
  • Pharmaceutics
  • Physical Pharmacy 
  • Dosage Forms Science 
  • Pharmaceutical Microbiology & Immunology 
  • Industrial Pharmacy 
  • Bio-Pharmaceutics 
  • Pharmaceutical Chemistry 
  • Pharmaceutical Instrumentation 
  • Medicinal Chemistry 
  • Pharmacognosy 
  • Physiology &Histology 
  • Anatomy & Pathology 
  • Pharmacology & Therapeutics 
  • Pharmacy Practice 
  • Pharmaceutical Mathematics   
  • Biostatistics 
  • Dispensing 
  • Community Social & Administrative Pharmacy 
  • Hospital Pharmacy 
  • Clinical Pharmacy 
  • Pharmaceutical Quality Management 
  • Forensic Pharmacy 
  • Pharmaceutical Technology 
  • Pharmaceutical Management & Marketing

Consortium Publisher is an online publisher that enjoys global presence with International Journals

Follow Us

©2009 - 2019 Consortium Publisher Canada

Contact Info

6252 Lisgar Dr Mississauga Ontario L5N7V2 Canada
+1 (647) 526-0885
office@consortiumpublisher.ca
http://www.consortiumpublisher.ca/