APPLICATION OF OPTIMIZATION TECHNIQUE IN SYNTHESIS AND CHARACTERIZATION OF SODIUM CARBOXY ETHYL GUAR.
Hasanpasha .N Sholapur, Fatima Sanjeri Dasankoppa, N.G.Nangundaswamy, Arunkumar G R
1 KLES College of Pharmacy, Vidyanagar, Hubli-31, Karnataka, India. 2 Dept. of Pharmaceutics, Government College of Pharmacy, Bangalore, Karnataka, India. 3 Fenny pharmacy, New Jersey, USA.
Keywords: Sodium carboxy ethyl guar (SCEG), synthesis, optimization technique (32 factorial design), characterization.
Abstract

Guar gum is a galactomannan polysaccharide obtained from the dried ripe seeds of Cyamopsis tetragonolobus. The objective of the present study was to derivatise guar gum to SCEG and to overcome limitations of guar gum viz, susceptible to microbial contamination, fall in viscosity on storage and to form a clear aqueous dispersion without imparting color to the formulation. The semisyntheic derivative of SCEG obtained by alcoholic alkali suspension method of guar gum was tried by applying optimization technique (32 factorial design) by altering the 2-chloropropionic acid:guar gum, percentage w/v ratio NaOH and temperature of the reaction mixture. The optimized polymer obtained from the various trials was subjected to physical, chemical and spectral characterization. Characterization revealed that derivatization of the guar gum to sodium carboxy ethyl guar. The derivatised polymer exhibited high stability at all ranges of temperature (50C, 250C, 370C and 450C), controlled rate of hydration, pseudoplastic flow pattern and less susceptibility to microbial contamination. Sodium carboxy ethyl guar solution is more controllable than gaur gum with regard to its thickening, viscosity building, suspending, film forming and excipent in the matrix tablets. The valid application of optimization technique was found to be highly productive in achieving an effective semisynthetic derivative meeting the ideal requirements.

Article Information

Identifiers and Pagination:
Year:2012
Volume:4
First Page:162
Last Page:171
Publisher Id:JAppPharm (2012 ). 4. 162-171
Article History:
Received:February 2, 2012
Accepted:March 28, 2012
Collection year:2012
First Published:April 1, 2012


© 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. You are free to: Share — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. No additional restrictions You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits
Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

Bibliography

Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

Subject & Scope
  • Pharmaceutics
  • Physical Pharmacy 
  • Dosage Forms Science 
  • Pharmaceutical Microbiology & Immunology 
  • Industrial Pharmacy 
  • Bio-Pharmaceutics 
  • Pharmaceutical Chemistry 
  • Pharmaceutical Instrumentation 
  • Medicinal Chemistry 
  • Pharmacognosy 
  • Physiology &Histology 
  • Anatomy & Pathology 
  • Pharmacology & Therapeutics 
  • Pharmacy Practice 
  • Pharmaceutical Mathematics   
  • Biostatistics 
  • Dispensing 
  • Community Social & Administrative Pharmacy 
  • Hospital Pharmacy 
  • Clinical Pharmacy 
  • Pharmaceutical Quality Management 
  • Forensic Pharmacy 
  • Pharmaceutical Technology 
  • Pharmaceutical Management & Marketing

Consortium Publisher is an online publisher that enjoys global presence with International Journals

Follow Us

©2009 - 2019 Consortium Publisher Canada

Contact Info

6252 Lisgar Dr Mississauga Ontario L5N7V2 Canada
+1 (647) 526-0885
office@consortiumpublisher.ca
http://www.consortiumpublisher.ca/