BIODISPOSITION KINETICS OF ISONIAZID IN HEALTHY FEMALES
Asia Parveen1,¥, Muhammad Sajid Hamid Akash2,3,*,¥, Kanwal Rehman2, Muhammad Tariq4, Nureen Zahra1, Tahira Iqbal5
1. Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan. 2. Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. 3. College of Pharmacy, Government College University Faisalabad, Faisalabad, Pakistan. 4. Department of Pharmacy, The University of Lahore, Lahore, Pakistan. 5. Department of chemistry and biochemistry, University of Agriculture Faisalabad, Pakistan.
Keywords: Isoniazid, Biodisposition kinetics, Female volunteers
Abstract

The aim of the study was to characterize the biodisposition kinetics parameters of Isoniazid after a single oral administration of 150mg tablet Isoniazid. The study was conducted on 6 healthy female volunteers with an average age of 21-22 years and an average body weight of 42-56 kg in the department of chemistry (Biochemistry) university of agriculture Faisalabad, Pakistan. Blood samples were collected after predetermined schedule and drug concentration was determined by using spectrophotometric method. The two compartment model kinetic analysis of plasma isoniazid concentration versus time data revealed estimated values of t1/2 ß, clearance and volume of distribution to be 7.60 ± 3.73h, 4.61± 2.69 1/h and 45.45 ± 22.35L respectively. Moreover, the area under curve (AUC), absorption rate constant (ka) and mean residence time (MRT) were observed to be 38.16± 13.76, 0.76±0.12 and 9.53± 4.21 respectively. In conclusion, the pharmacokinetic parameters observed for isoniazid in current study were found to be significantly different from some of the previously reported literature, suggesting that an adequate and rational dosage regimen of drug requires a disposition study of parameters under specific indigenous environment prior to their administration.

Article Information

Identifiers and Pagination:
Year:2012
Volume:4
First Page:227
Last Page:232
Publisher Id:JAppPharm (2012 ). 4. 227-232
Article History:
Received:June 3, 2012
Accepted:September 15, 2012
Collection year:2012
First Published:October 1, 2012


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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
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Starting year: 2009
Nature: Online 
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