PLASMA LIPID ALTERATIONS IN LEUKEMIA PATIENTS
M. Imran Qadir1, M. Saleem1, Syed Haroon Khalid2, Salman Akbar Malik3, Asif Massud1, Mohsin Ali1, Sajid Asghar1 and M. Sajid Hamid Akash1
1. College of Pharmacy, GC University, Faisalabad, Pakistan 2. School of Pharmaceutical Sciences, University Sains Malaysia, Pulau Pinang, Malaysia 3. Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
Keywords: Cancers, Leukemia, Plasma lipid profile, Triglycerides, Cholesterol, LDL-Cholesterol and HDL-Cholesterol
Abstract

Neoplastic disease indicates a disease of new growth. Neoplasms or tumors may be divided into two categories; benign tumors and malignant tumors. Benign tumors are relatively innocent and remain localized. Malignant tumors are also called cancers and are distinguished from benign tumors by the properties of invasiveness and metastasis. Cancer of the leukocytes and their precursors is known as leukemia. Triglycerides, cholesterol, LDL-cholesterol and HDL-cholesterol constitute plasma lipid profile. Objective of the present study was to investigate relationship of plasma lipid profile (Triglycerides, Cholesterol, LDL-Cholesterol and HDL-Cholesterol) with leukemia. 180 subjects were included in the study. The subjects comprised of two groups; first as Controls (90 in number) and the second as Patients of Leukemia (also 90 in number). Fasting blood samples were collected for estimation of plasma lipid levels. Comparison between mean values of plasma lipid profile of control subjects and leukemia patients indicated that there was moderate decrease in all plasma levels of leukemia patients: triglycerides (31.29%, P < 0.01), cholesterol (27.15%, P < 0.01), LDL-cholesterol (23.28%, P < 0.01) and HDL-cholesterol (24.70%, P<0.05). As there is a change in plasma lipid profile of leukemia patients, the plasma lipid profile may be used as adjuvant for identification of the disease along with the standard diagnostics tools.

Article Information

Identifiers and Pagination:
Year:2011
Volume:3
First Page:45
Last Page:50
Publisher Id:JAppPharm (2011 ). 3. 45-50
Article History:
Received:September 11, 2010
Accepted:January 7, 2011
Collection year:2010
First Published:January 11, 2011


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

Bibliography

Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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