PLASMA LIPID ALTERATIONS IN LEUKEMIA PATIENTS
M. Imran Qadir1, M. Saleem1, Syed Haroon Khalid2, Salman Akbar Malik3, Asif Massud1, Mohsin Ali1, Sajid Asghar1 and M. Sajid Hamid Akash1
1. College of Pharmacy, GC University, Faisalabad, Pakistan
2. School of Pharmaceutical Sciences, University Sains Malaysia, Pulau Pinang, Malaysia
3. Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
Keywords: Cancers, Leukemia, Plasma lipid profile, Triglycerides, Cholesterol, LDL-Cholesterol and HDL-Cholesterol
Neoplastic disease indicates a disease of new growth. Neoplasms or tumors may be divided into two categories; benign tumors and malignant tumors. Benign tumors are relatively innocent and remain localized. Malignant tumors are also called cancers and are distinguished from benign tumors by the properties of invasiveness and metastasis. Cancer of the leukocytes and their precursors is known as leukemia. Triglycerides, cholesterol, LDL-cholesterol and HDL-cholesterol constitute plasma lipid profile. Objective of the present study was to investigate relationship of plasma lipid profile (Triglycerides, Cholesterol, LDL-Cholesterol and HDL-Cholesterol) with leukemia. 180 subjects were included in the study. The subjects comprised of two groups; first as Controls (90 in number) and the second as Patients of Leukemia (also 90 in number). Fasting blood samples were collected for estimation of plasma lipid levels. Comparison between mean values of plasma lipid profile of control subjects and leukemia patients indicated that there was moderate decrease in all plasma levels of leukemia patients: triglycerides (31.29%, P < 0.01), cholesterol (27.15%, P < 0.01), LDL-cholesterol (23.28%, P < 0.01) and HDL-cholesterol (24.70%, P<0.05). As there is a change in plasma lipid profile of leukemia patients, the plasma lipid profile may be used as adjuvant for identification of the disease along with the standard diagnostics tools.