ASSESSMENT OF THYROID HORMONES LEVEL IN PREMENOPAUSAL AND POSTMENOPAUSAL FEMALES
Tasnim Farasat1, Ayesha Liaqat1, Tahira Mughal2
1. Department of Zoology, Lahore College for Women University, Lahore, Pakistan 2. Department of Botany Lahore College for Women University, Lahore, Pakistan
Keywords: Thyroid dysfunction, hypothyroid, hyperthyroid
Abstract

Thyroid dysfunction is the common endocrine disorder and females are more affected than males. The aim of this study was to assess the serum thyroid hormone level in premenopausal and postmenopausal females with thyroid dysfunction and observe the effect of thyroid dysfunction on body weight and menstrual regularity. Total 91 female subjects were included in the study. Serum thyroid hormone levels of TSH, FT3 and FT4 were assessed by ELISA technique. It was observed that serum TSH levels were significantly higher in premenopausal and postmenopausal hypothyroid females groups (P<0.01) as compared to the control group with normal thyroid function. Demographic characteristics and disease history of the subject were collected. In hyperthyroid premenopausal females serum TSH level was significantly lower than the control group (P<0.01). Serum FT3 level was significantly higher in hyperthyroid premenopausal and postmenopausal females as compared to control group (P<0.01). In this study, 80% of premenopausal hypothyroid females and 65% of hyperthyroid females complained about menstrual irregularities, this percentage is high as compared to control subjects, which is 20% (P<0.01). Inverse negative correlation was observed between TSH, T3, TSH, and T 4, whereas positive correlation was observed between T3 and T 4. Thyroid dysfunction can lead to menstrual irregularities

Article Information

Identifiers and Pagination:
Year:2011
Volume:3
First Page:179
Last Page:190
Publisher Id:JAppPharm (2011 ). 3. 165-178
Article History:
Received:February 9, 2011
Accepted:March 23, 2011
Collection year:2011
First Published:April 13, 2011


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

Bibliography

Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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