PREVALENCE AND RISK FACTORS OF ANTITUBERCULAR DRUG-INDUCED HEPATITIS IN URBAN POPULATION OF BAHAWALPUR DISTRICT, PUNJAB-PAKISTAN
Rifat-uz-Zaman
Department of Pharmacy, Islamia University, Bahawalpur-Pakistan.
Keywords: anti-tuberculosis drugs, drug induced hepatitis, extrapulmonary tuberculosis, hepatoxicity, isoniazid, pyrazinamide, rifampin, toxic hepatitis
Abstract

Introduction: Tuberculosis (TB) infects one third of population, world over. Anti-tubercular like isoniazid, rifampicin and pyrazinamide are highly effective but hepatotoxic. Data on prevalence of anti-TB drug-induced hepatitis and contributing risk factors are scarce in Bahawalpur. This cross-sectional study was designed to look at the prevalence and promoting risk factors of druginduced hepatitis in the urban population of Bahawalpur district, Punjab- Pakistan. Methods: We examined a total of 1161 peoples (>15 years; 589 male and 572 female); divided into 3 groups i.e., young (1535 years), mature (3550 years) and old (>50 years). Population was compared in terms of demographical data and risk factors, such as age, gender, hepatitis B/C carrier, and pretreatment liver biochemistries (serum albumin, globulin, aspartate aminotransferase, alanine aminotransferase and bilirubin). Data was evaluated by 95% confidence interval. Differences were considered significant at p<0.05 and highly significant at p<0.001. Results: Out of 146 TB patients, 21 developed hepatitis. The prevalence of drug-induced hepatitis was 14.38%. Lower serum albumin (p<0.05), higher serum globulin (p<0.05), tuberculosis, hepatitis B/C and poverty were significant risk factors. Conclusion: ATB-induced hepatotoxicity was significantly frequent among the patients treated with ATB.

Article Information

Identifiers and Pagination:
Year:2011
Volume:3
First Page:221
Last Page:233
Publisher Id:JAppPharm (2011 ). 3. 221-233
Article History:
Received:January 6, 2011
Accepted:April 5, 2011
Collection year:2011
First Published:April 13, 2011


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

Bibliography

Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
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Language: English

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