FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF CANDESARTAN CILEXETIL USING NATURAL AND SYNTHETIC SUPERDISINTEGRANTS
Basawaraj S.Patil1*, N.G.Raghavendra Rao2
1Research scholar, Singhania University, Pacheri Bari, Dist. Jhunjhunu - Rajasthan, India 2Department of Pharmaceutics, Luqman College of Pharmacy, Gulbarga – Karnataka, India
Keywords: Candesartan cilexetil, Fast dissolving tablets, Plantago ovata mucilage, Superdisintegrants.
Abstract

In the present work attempts were made to prepare fast dissolving tablets (FDT) of candesartan cilexetil by direct compression method with a view to enhance patient compliance. The synthetic and natural superdisintegrants used in this study were croscarmellose sodium, and plantago ovata mucilage. Tablets having superdisintegrant at different concentration (2.5, 5, 7.5 and 10 mg) level were prepared. The prepared batches of tablets were evaluated for uniformity of weight, thickness, hardness, friability, drug content, wetting time, in vitro dispersion time and in vitro dissolution study. Swelling index was also investigated with an aim to compare the swelling property of plantago ovata mucilage with synthetic superdisintegrant. Compare to croscarmellose sodium, plantago ovata mucilage showed the highest swelling index. Hence, the present work revealed that this natural superdisintegrant, plantago ovata mucilage showed better disintegrating property than the most widely used synthetic superdisintegrants in the formulation of fast dissolving tablets.

Article Information

Identifiers and Pagination:
Year:2011
Volume:3
First Page:250
Last Page:261
Publisher Id:JAppPharm (2011 ). 3. 250-261
Article History:
Received:March 9, 2011
Accepted:June 11, 2011
Collection year:2011
First Published:July 5, 2011


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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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