IN VIVO ANTIOXIDANT ACTIVITY OF PHYLLANTHUS EMBLICUS AGAINST CISPLATIN INDUCED OXIDATIVE STRESS IN MICE
Mamuna Naz, Uzma Saleem, Bashir Ahmad
Faculty of Pharmacy, The University of Lahore, Lahore-Pakistan.Assistant Professor, Faculty of Pharmaceutical Sciences, G. C. University, Faisalabad-Pakistan. Director / Professor, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore-Pakistan.
Keywords: In vivo antioxidant activity, hypolipidemic, hepato-renal curative
Abstract

Background: Plants are rich source of antioxidants. They can ameliorate the oxidative stress induced complications. Cisplatin is a cytotoxic drug which produced unwanted effects in the patients due to generation of free radicals inside the body. Phyllanthus emblicuspossessed in vitro antioxidant activity. Objective: The current study was aimed to explore in vivo antioxidant potential of Phyllanthus emblicus against the oxidative stress induced by cisplatin in mice. Method: oxidative stress was induced in micewith acute toxic dose (10 mg/kg) of cisplatin given i.p. Animals were divided into five groups (n = 5). Group I: negative control, group II: positive control group III and IV were given methanol extract ofPhyllanthus emblicus (250- & 500 mg/kg; orally respectively) and group V was standard group receiving orally vitamin C & E (200 mg/kg each) for 20 days. On 21st day, animals were sacrificed and oxidative stress biomarkers were quantified. Result: Phyllanthus emblicusextract showed vigorous in vivo antioxidant effect at 500mg/kg by increasing the SOD, CAT, and GSH (antioxidant enzymes) levels in heart, liver, kidney and brain homogentaes and MDA level decreased. Plant also displayed a cure against oxidative stress induced changes in renal, liver and lipid profile parameters. Conclusion: Phyllanthus emblicusraised antioxidant enzyme levels in mice. It manifested hypolipidemic, hepato-renal curative effects. Its adjuvant use with standard therapies may help to resolve unwanted effects.

Article Information

Identifiers and Pagination:
Year:2016
Volume:8
First Page:1
Last Page:6
Publisher Id:19204159.8:1.2016
Article History:
Received:October 06,2015
Accepted:November 13,2015
Collection year:2015
First Published:January 1, 2016


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Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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