SYNTHESIS AND ANTIMICROBIAL EVALUATION OF CERTAIN ARYLAZO IMIDAZOLES
M. Sreedevi Meesaraganda, Raghavendra Guru Prasad Aluru, ..
1. Sri Kirshnadevaraya University, Anantapur, A.P., India.
2. ICFAI Foundation for Higher Education, Hyderabad, A.P., India.
Keywords: Arylazo imidazoles, Elemental analysis, IR spectra, 1H NMR spectra, Antimicrobial screening.
Seven novel arylazo imidazoles were synthesized and structures have been elucidated on the basis of elemental analysis, IR and 1H NMR spectral data. Antibacterial activity studies was done against two gram positive bacteria (S. aureus, P.aeruginosa,) and two gram negative bacteria (E.coli and B.subtili), while antifungal activity studies was done against C.albicans and A.nigerz. Minimum inhibitory concentration was found out by Serial dilution method. Antibacterial and antifungal activity studies of the title compounds (IIIa-IIIe) was compared with standards namely Furacin and Flucanazole. All the synthesized arylazo imidazoles have shown significant activity against the tested microbes. The compounds IIIb, IIIc and IIId exhibit relatively higher activity than the standards.
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