STUDY OF THE CHEMICAL AND METABOLIC CHANGES IN PLASMA
GLUTATHIONE (GSH) OF HUMAN BLOOD AFTER LITHIUM INTRODUCTION
1Haroon Khan, 1Muhammad Farid Khan, 2Syed Umer Jan*, 1Kamran Ahmad Khan and
1Shefaat Ullah Shah
1Faculty of Pharmacy, Gomal University Dera Ismail Khan (KPK) Pakistan
2 Department of Pharmacy, University of Balochistan, Quetta Pakistan
Keywords: Lithium, Glutathione (GSH), Blood, Plasma, Ellman’s method
Lithium remains a mainstay in the acute and prophylactic treatment of bipolar affective
disorder. It is used in the augmentation of antidepressant treatment and, less frequently, in
the augmentation of antipsychotic treatment of schizophrenia. It is reported to have
specific anti-suicidal effects. Systematic reviews by the Cochrane collaboration and
others have examined the evidence base or its use in these contexts. Thus it is interesting
to study the effect of Lithium on the Glutathione. The effect of Lithium on the chemical
status of the glutathione in plasma has been studied using Ellman’s method. The effect of
Lithium on the chemical status of glutathione was determined in plasma for concentration
and time dependent effects. There was found a drastic effect on decreasing the
concentration of glutathione in plasma as the concentration is increased and time has
passed. The decrease in the Glutathione level was concentration and time of interaction
dependent, probably due to oxidation of GSH to corresponding disulphide (GSSG).In this
paper the effect of Lithium metal on thiol /GSH level was discussed in vitro, which in
principal may present a model of in vivo reaction.
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