PREVALENCE AND RISK FACTORS OF ANTITUBERCULAR DRUG-INDUCED
HEPATITIS IN URBAN POPULATION OF BAHAWALPUR DISTRICT,
Department of Pharmacy, Islamia University, Bahawalpur-Pakistan.
Keywords: anti-tuberculosis drugs, drug induced hepatitis, extrapulmonary tuberculosis, hepatoxicity, isoniazid, pyrazinamide, rifampin, toxic hepatitis
Introduction: Tuberculosis (TB) infects one third of population, world over.
Anti-tubercular like isoniazid, rifampicin and pyrazinamide are highly effective
but hepatotoxic. Data on prevalence of anti-TB drug-induced hepatitis and
contributing risk factors are scarce in Bahawalpur. This cross-sectional study
was designed to look at the prevalence and promoting risk factors of druginduced
hepatitis in the urban population of Bahawalpur district, Punjab-
Methods: We examined a total of 1161 peoples (>15 years; 589 male and
572 female); divided into 3 groups i.e., young (1535 years), mature (3550
years) and old (>50 years). Population was compared in terms of
demographical data and risk factors, such as age, gender, hepatitis B/C
carrier, and pretreatment liver biochemistries (serum albumin, globulin,
aspartate aminotransferase, alanine aminotransferase and bilirubin). Data was
evaluated by 95% confidence interval. Differences were considered significant
at p<0.05 and highly significant at p<0.001.
Results: Out of 146 TB patients, 21 developed hepatitis. The prevalence of
drug-induced hepatitis was 14.38%. Lower serum albumin (p<0.05), higher
serum globulin (p<0.05), tuberculosis, hepatitis B/C and poverty were
significant risk factors.
Conclusion: ATB-induced hepatotoxicity was significantly frequent among the
patients treated with ATB.