CONCENTRATION AND TIME DEPENDENT EFFECT OF ALUMINIUM METAL ON GLUTATHIONE LEVEL IN PLASMA OF HUMAN BLOOD
Haroon Khan1, Muhammad Farid Khan1, Syed Umer Jan1, Kamran Ahmad Khan1, Kifayat Ullah Shah1 And Ameer Badshah3
1Faculty of Pharmacy, Gomal University Dera Ismail Khan (KPK) Pakistan
2 Department of Pharmacy, University of Balochistan, Quetta Pakistan
Keywords: Aluminium (Al), Glutathione (GSH), Ellman’s method. 5, 5-Dithiobis, 2-Nitrobenzoic
Aluminium is an important metalloelement and has many medicinal uses like use of aluminum as
an antacid. Thus it is interesting to study the effect of Aluminium on the glutathione (GSH) in
vivo conditions. The concentration and time dependent effect of Aluminium on glutathione level
in plasma was studied by using Ellman’s method. A drastic effect on decreasing the
concentration of glutathione level in plasma was found by increasing the concentration of
Aluminium sulphate over the time. The reason could probably be due to oxidation of GSH to
corresponding disulphide (GSSG). In this paper the effect of Aluminium metal on thiol/GSH
level was discussed in vitro, which in principal may present a model of in vivo reaction.
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