GASTRIC- MUCOADHESIVE DRUG DELIVERY SYSTEMS OF CAPTOPRIL
Altaf M.A1.*, Imran A2. Sholapur H.P3
1. Department of Pharmacy, IBNSINA National Medical College Jeddah KSA 2. Department of Pharmaceutics RMES College of Pharmacy Gulbarga India 3. Department of Pharmacognosy KLES College of Pharmacy Hubli. India
Keywords: Captopril, controlled release, orifice gelation, beads, mucoadhesion, oral drugdelivery systems, sodium alginate.
Abstract

A new oral drug delivery system was developed utilizing both the concepts ofcontrolled release and mucoadhesiveness, in order to obtain a unique drug delivery system which could remain in stomach and control the drug release for longer period of time. Gastro-retentive beads of captopril were prepared by orifice ionicgelation method in 1:1 and 9:1 ratio of alginate along with mucoadhesive polymers viz; hydroxyl propyl methyl cellulose, carbopol 934P, chitosan and cellulose acetate phthalate. The prepared beads were subjected for various evaluation parameters. The percentage drug content was found to be in the range of 59.4 - 91.9 percent forbeads. It was observed that as the alginate proportion was increased, the average size of beads also increased. Photomicrographs revealed that the beads were spherical in shape. Alginate-chitosan (9:1) beads showed excellent microencapsulation efficiency (89.7 percent). Alginate-Carbopol 934P exhibited maximum efficiency of mucoadhesion in 0.1 N HCl (44 percent for 1:1 and 22 percent for 9:1) at the end of 8 hours, whereas least mucoadhesion was observed with alginate-Cellulose acetate phthalate beads. The in vitro release studies were carried out in 0.1 N hydrochloric acid and the release were found to be more sustained with Alginate-chitosan beads (9:1) than Alginate-Carbopol 934P (1:1) beads. The alginate-cellulose acetate phthalate beads showed the better sustained release as compared to all other alginate-polymer combinations. Regression analysis showed that the release followed zero order kinetics in 0.1 N HCl (pH 1.2).

Article Information

Identifiers and Pagination:
Year:2011
Volume:3
First Page:346
Last Page:358
Publisher Id:JAppPharm (2011 ). 3. 246-358
Article History:
Received:June 16, 2011
Accepted:September 17, 2011
Collection year:2011
First Published:October 1, 2011


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

Bibliography

Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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