GC-MS ANALYSIS AND ANTIULCER ACTIVITY OF ETHANOL EXTRACT OF TUBERS OF MOMORDICA TUBEROSA COGN. (CUCURBITACEAE) IN RATS
Pramod Kumar*1, Devala Rao G2, Lakshmayya3, Ramachandra Setty S4
1 Department of Pharmacognosy, V.L. College of Pharmacy, Raichur-584103 2 KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada- 520010 3 GRD Institute of Management and Technology (Pharmacy), Dehradun-248001 4 Govt. College of Pharmacy, Bengaluru- 560027, India
Keywords: Anti-oxidant, Aspirin, Ethanol, Free acidity, Pyloric ligation, Total acidity.
Abstract

70% ethanol extract of tubers of Momordica tuberosa (TMT) showed the presence of saponins and triterpenoids. GC-MS analysis of the extract showed presence of 42 compounds with Isopulegol, a monoterpene and a steroid, Androstane as main constituents. Many fatty acid derivatives like myristic acid, margaric acid, oleic acid etc. were also present. The extract was then tested for its antiulcer activity using three different experimental models of ulcers in rats viz., aspirin, ethanol and pyloric ligation induced ulcers in rats. The LD50 in rat was 200mg/kg. One fifth and one tenth of maximum dose i.e.40 and 20mg/kg were used to assess the antiulcer activity. In pylorus ligation model, parameters like ulcer index, volume of gastric juice, free acidity, total acidity and pH were measured. The extract showed antiulcer activity in a dose dependant manner. The 40mg/kg dose reduced ulcer to an extent of 95% in aspirin model and 82% in pyloric ligation method. The results suggest the anti-ulcer activity of tubers of Momordica tuberosa, probably due to its antioxidant nature.

Article Information

Identifiers and Pagination:
Year:2011
Volume:3
First Page:359
Last Page:269
Publisher Id:JAppPharm (2011 ). 3. 259-269
Article History:
Received:May 21, 2011
Accepted:September 11, 2011
Collection year:2011
First Published:October 10, 2011


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

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Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
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