PHARMACOLOGICAL SCREENING OF EUPHORBIA NERIIFOLIA LEAF HYDROALCOHOLIC EXTRACT
Papiya Bigoniya1, A.C. Rana2
1. Radharaman College of Pharmacy, Radharaman Group of Institutes, Ratibad, Bhopal-02, M.P., India 2. Rayat College of Pharmacy, Rail Majra, Ropar-144553, Punjab, India
Keywords: Pharmacological screening of Euphorbia neriifolia Linn. (Euphorbiaceous) leaf hydro alcoholic extract were performed to explore the analgesic, anti-inflammatory, diuretic, antidiarrhoeal and antiulcer activities. All tests were conducted on rats using 100, 200 and 400 mg/kg dose as LD50 of extract was found to 2779.71 mg/kg. Study revealed strong analgesic effect of E. neriifolia against thermal (P<0.001), and in mechanical and chemical (p < 0.01) noxious stimuli and anti-inflammatory activity (P<0.001 to 0.01) at the 1000 mg/kg dose. In carrageenan-induced paw edema and cotton pellet induced granuloma model E. neriifolia extract showed significant (P<0.001 to 0.01) antiinflammatory activity. Extract considerably increases urine volume as an effective hypernatraemic and hyperchloraemic diuretic. E. neriifolia showed laxative property by increasing wet defecation along with castor oil. Extract showed very prominent protection against ethanol-induced ulceration as well as on pyloric ligated ulceration in dose dependent manner. Extract increases total hexoses (P<0.001), hexosamine (P<0.05), sialic acid and total carbohydrate content (P<0.001) with a decrease in total protein content (P<0.001) of gastric mucosa at 400 mg/kg dose. Presence of phytoconstituents like tannins, flavonoids, alkaloids and triterpenoidal saponins may be responsible for the found pharmacological activities.
Abstract

Euphorbia neriifolia, analgesic, anti-inflammatory, diuretic, laxative, antiulcer

Article Information

Identifiers and Pagination:
Year:2010
Volume:2
First Page:1
Last Page:17
Publisher Id:JAppPharm (2010 ). 2. 1-17
Article History:
Received:September 2009
Accepted:December 4, 2009
Collection year:2009
First Published:January 13, 2010


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
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Starting year: 2009
Nature: Online 
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Language: English

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