ANTIBACTERIAL AND SYNERGISTIC STUDIES OF SALSOLA KALI
Tahira Mughal1, Ismat Naeem2, Muhammad Tahir Aziz3, Afshan Ahsan1
1. Department of Botany, Lahore College for Women University, Jail Road, Lahore, Pakistan 2. Department of Chemistry, Lahore College for Women University, Jail Road, Lahore, Pakistan 3. Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore Pakistan
Keywords: Salsola kali, Antibacterial activity, Synergistic activity Heliotropium strigosum, Galium asperuloides, Senecio chrysanthemoides,
Abstract

Salsola kali is an annual herb, found near the Bahawalpur (Cholistan desert) South Punjab, Pakistan. Extract of aerial part of the plant in methanol was tested for antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Streptococcus pneumoniae, Bacillus subtilis, Streptococcus mutans and Sarcina lutae. Methanol was found to be best antimicrobial solvent. Minimum Inhibitory Concentration (MIC) of methanolic extract was determined and found to be bactericidal in concentration of 0.5 µg/ml against Staphylococcus aureus, S. pneumoniae, Bacillus subtilis and Streptococcus mutans. Synergistic antibacterial activity of methanolic extracts was tested with respective solvent extracts of aerial parts of the Heliotropium strigosum, Galium asperuloides and Senecio chrysanthemoides synergistically showed best antibacterial activity against all the bacteria (0.5 µg/ml). The extract of Salsola kali and the methanolic extract of Galium asperuloides showed best activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Streptococcus mutans (0.5µg/ml). Synergistically Salsola kali with Senecio chrysanthemoides showed best activity against all the bacterial strains (0.5µg/ml) except S. lutae and S. mutans . Salsola kali with Heliotropium strigosum showed best activity against E. coli, S. pneumoniae, B. subtilis, S. lutae and S. mutans (0.5µg/ml) and inhibited the growth of Staphylococcus aureus and Pseudomonas aeruginosa.

Article Information

Identifiers and Pagination:
Year:2010
Volume:2
First Page:18
Last Page:26
Publisher Id:JAppPharm (2010 ). 2. 18-26
Article History:
Received:July 3, 2009
Accepted:November 27, 2009
Collection year:2009
First Published:January 13, 2010


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Editor in Chief
Prof. Dr. Cornelia M. Keck (Philipps-Universität Marburg)
Marburg, Germany

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Welcome to the research group of Prof. Dr. Cornelia M. Keck in Marburg. Cornelia M. Keck is a pharmacist and obtained her PhD in 2006 from the Freie Universität (FU) in Berlin. In 2009 she was appointed as Adjunct Professor for Pharmaceutical and Nutritional Nanotechnology at the University Putra Malaysia (UPM) and in 2011 she obtained her Venia legendi (Habilitation) at the Freie Universität Berlin and was appointed as a Professor for Pharmacology and Pharmaceutics at the University of Applied Sciences Kaiserslautern. Since 2016 she is Professor of Pharmaceutics and Biopharmaceutics at the Philipps-Universität Marburg. Her field of research is the development and characterization of innovative nanocarriers for improved delivery of poorly soluble actives for healthcare and cosmetics. Prof. Keck is executive board member of the German Association of Nanotechnology (Deutscher Verband Nanotechnologie), Vize-chairman of the unit „Dermocosmetics“ at the German Society of Dermopharmacy, active member in many pharmaceutical societies and member of the BfR Committee for Cosmetics at the Federal Institute for Risk Assessment (BfR).

Journal Highlights
Abbreviation: J App Pharm
doi: http://dx.doi.org/10.21065/19204159
Frequency: Annual 
Current Volume: 9 (2017)
Next scheduled volume: December, 2018 (Volume 10)
Back volumes: 1-9
Starting year: 2009
Nature: Online 
Submission: Online  
Language: English

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